Reducing human suffering and mortality through novel drug discovery

Reducing human suffering and mortality through novel drug discovery

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Reducing human suffering and mortality through novel drug discovery

ABOUT US

The Low Institute for Therapeutics

The Low Institute for Therapeutics (LIFT) is a non-profit drug discovery institute dedicated to reducing human suffering and mortality through research and drug discovery. The institute was founded to advance and accelerate the pioneering drug discovery work conducted at Purdue University in the lab of Dr Phil Low, Presidential Scholar for Drug Discovery and Ralph C. Corley Distinguished Professor of Chemistry and Biochemistry by bridging the gap between academic discovery and for-profit clinical development.

With over 50 years of research and drug discovery experience, the Low Lab at Purdue has discovered three FDA approved drugs (PLUVICTO, LOCAMETZ, CYTALUX) and five investigational drugs currently in human clinical trials, and holds over 100 approved patents.

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our core duty

Science

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our core duty

Science

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Solid Tumors and Metastatic Cancer

Precision medicines which selectively attack cancer cells while sparing healthy tissue

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Regenerative Medicine

Drug-based strategies that promote tissue and organ repair, including bone and soft tissue regeneration.

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Fibrotic Diseases

Therapies targeting cellular mechanisms
behind fibrosis across organ systems

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World 
Diseases

New mechanisms of action to treat diseases such as malaria and sickle cell disease

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Immune-Mediated Disorders

Compounds that reprogram immune cells to combat inflammation, cancer, and autoimmune disorders

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Help us develop

LIFT is focusing on disease areas that matter most, including hard-to-treat cancers, chronic kidney disease, pulmonary fibrosis, heart failure, rheumatoid arthritis, organ transplant rejection, fatty liver disease, Alzheimer’s disease, sickle cell disease and bone fractures.

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Know us better

Our Team

The Low Institute for Therapeutics (LIFT) is a non-profit drug discovery institute dedicated to reducing human suffering and mortality through research and drug discovery.

Phil Low, PhD

Co-Founder and Chairman of the Board

Dr. Philip Low is the Presidential Scholar for Drug Discovery and the RC Corley Distinguished Professor of Chemistry at Purdue University, where he directs a lab of ~35 graduate students/postdocs and ~50 undergraduate researchers.

Jeff Pickett

Co-Founder and Founding Donor

Jeff Pickett is a Co-Founder at the Low Institute for Therapeutics (LIFT). He is the founder of Connor Group, a premier global professional services firm specializing in technical accounting, financial operations, and IPO services.

Benjamin Lundgren

Co-Founder and Managing Director

Benjamin Lundgren is Managing Director at Low Institute for Therapeutics (LIFT). A 20-year healthcare veteran, he has extensive experience bringing novel pharmaceuticals and medical devices to market.

Stewart Low, PhD

CO-founder and Executive Director

Stewart Low is the Executive Director at the Low Institute for Therapeutics (LIFT), where he leverages his extensive experience in advancing novel pharmaceuticals from academic research to clinical studies.

Phil Low, PhD

Co-Founder and Chairman of the Board

Dr. Philip Low is the Presidential Scholar for Drug Discovery and the RC Corley Distinguished Professor of Chemistry at Purdue University, where he directs a lab of ~35 graduate students/postdocs and ~50 undergraduate researchers.

Jeff Pickett

Co-Founder and Founding Donor

Jeff Pickett is a Co-Founder at the Low Institute for Therapeutics (LIFT). He is the founder of Connor Group, a premier global professional services firm specializing in technical accounting, financial operations, and IPO services.

Benjamin Lundgren

Co-Founder and Managing Director

Benjamin Lundgren is Managing Director at Low Institute for Therapeutics (LIFT). A 20-year healthcare veteran, he has extensive experience bringing novel pharmaceuticals and medical devices to market.

Stewart Low, PhD

CO-founder and Executive Director

Stewart Low is the Executive Director at the Low Institute for Therapeutics (LIFT), where he leverages his extensive experience in advancing novel pharmaceuticals from academic research to clinical studies.

Phil Low, PhD

Co-Founder and Chairman of the Board

Dr. Philip Low is the Presidential Scholar for Drug Discovery and the RC Corley Distinguished Professor of Chemistry at Purdue University, where he directs a lab of ~35 graduate students/postdocs and ~50 undergraduate researchers.

Jeff Pickett

Co-Founder and Founding Donor

Jeff Pickett is a Co-Founder at the Low Institute for Therapeutics (LIFT). He is the founder of Connor Group, a premier global professional services firm specializing in technical accounting, financial operations, and IPO services.

Benjamin Lundgren

Co-Founder and Managing Director

Benjamin Lundgren is Managing Director at Low Institute for Therapeutics (LIFT). A 20-year healthcare veteran, he has extensive experience bringing novel pharmaceuticals and medical devices to market.

Stewart Low, PhD

CO-founder and Executive Director

Stewart Low is the Executive Director at the Low Institute for Therapeutics (LIFT), where he leverages his extensive experience in advancing novel pharmaceuticals from academic research to clinical studies.

Discover more about our Team >

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Publications

The Low Institute for Therapeutics (LIFT) is a non-profit drug discovery institute dedicated to reducing human suffering and mortality through research and drug discovery.

Discover more publications >

Design of a Fibroblast Activation Protein–Targeted Radiopharmaceutical Therapy with High Tumor–to–Healthy-Tissue Ratios

Because of upregulated expression on cancer-associated fibroblasts, fibroblast activation protein (FAP) has emerged as an attractive biomarker for the imaging and therapy of solid tumors.

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Targeted Delivery of Abaloparatide to Spinal Fusion Site Accelerates Fusion Process in Rats

An oligo-glutamate–conjugated abaloparatide homes to spinal fusion sites and, in rats, outperforms topical BMP-2—speeding mineralization, boosting fusion rates, and avoiding ectopic bone or toxicity.

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Selective reprogramming of regulatory T cells in solid tumors can strongly enhance or inhibit tumor growth

Folate receptor delta (FRδ) has been used as a biomarker for regulatory T cells (Tregs), because its expression is limited to Tregs and ovum.

Open link >

Design of a Fibroblast Activation Protein–Targeted Radiopharmaceutical Therapy with High Tumor–to–Healthy-Tissue Ratios

Because of upregulated expression on cancer-associated fibroblasts, fibroblast activation protein (FAP) has emerged as an attractive biomarker for the imaging and therapy of solid tumors.

Read more >

Targeted Delivery of Abaloparatide to Spinal Fusion Site Accelerates Fusion Process in Rats

An oligo-glutamate–conjugated abaloparatide homes to spinal fusion sites and, in rats, outperforms topical BMP-2—speeding mineralization, boosting fusion rates, and avoiding ectopic bone or toxicity.

Read more >

Selective reprogramming of regulatory T cells in solid tumors can strongly enhance or inhibit tumor growth

Folate receptor delta (FRδ) has been used as a biomarker for regulatory T cells (Tregs), because its expression is limited to Tregs and ovum.

Read more >
Discover more publications >

work together

Careers

Join our exceptional team of specialists in such fields as business,  science and technology and become a part of our innovative research  group.

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News about us

News

Explore the latest updates on our research programs, grants, and emerging therapies developed at the Low Institute for Therapeutics. Follow the links to track progress and scientific breakthroughs from our teams.

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Contact Us

Low Institute For Therapeutics
3000 Kent Ave, Suite 1956
West Lafayette, IN 47906

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Contact Us

Low Institute For Therapeutics
3000 Kent Ave, Suite 1956
West Lafayette, IN 47906

WATCH US